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Article

Rac1 is deactivated at integrin activation sites via an IQGAP1/filamin-A/RacGAP1 pathway

1 Jan 2013

Abstract excerpt

Cell migration makes a fundamental contribution to both normal physiology and disease pathogenesis. Integrin engagement with extracellular ligands spatially controls, via the cyclical activation and deactivation of the small GTPase Rac1, the dynamic membrane protrusion and cytoskeletal reorganization events that are required for directional migration. Although the pathways that control integrin-mediated Rac1...

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PMID: 23843620
DOI: 10.1242/jcs.121988

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