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Article

Teeter-Totter-Like Redistribution of Switch I: Integrating Simulation and Experiment to Uncover the Molecular Basis of Oncogenic Rac1Mutations.

Journal of chemical information and modeling - 24 Aug 2026

Li Shuo, Hu Yuhao, Zhou Kaixiao, Wei Xubiao, Liu Shengtang, Jiang Yabo, Yang Zaixing, Jiao Yang, Meng Xuanyu

Abstract excerpt

Rac1 is a small GTPase of the Rho family. It is a central regulator of cytoskeletal remodeling, cell adhesion, migration, and secretion. Dysregulation of Rac1 activity drives tumorigenesis, with the cancer-associated P29S mutation ranking as the third most frequently mutated proto-oncogene in sun-exposed melanoma. P29S is a prototypical gain-of-function, fast-cycling variant that destabilizes GDP binding and...

Read the complete abstract on PubMed

Topics

rac1 GTP-Binding Protein
Molecular Dynamics Simulation
Humans
Proto-Oncogene Mas
Mutation
Guanosine Diphosphate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Guanosine Triphosphate

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Identifiers

PMID: 42670849
DOI: 10.1021/acs.jcim.5c02116

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