How Functional Variants Reconfigure the Rac2 Conformational Landscape

Abstract excerpt

Rac2, a member of the Rho family of small GTPases, is a fundamental regulator of essential cellular processes. Pathogenic substitutions near and within the Switch II region, specifically D57N and E62K, have been implicated in oncogenesis and immunodeficiency. Despite their proximity, D57N is characterized as a loss-of-function mutation, while E62K is a constitutively active, gain-of-function mutation. In this stud...

Topics

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• Erythrocyte Function and Pathophysiology
• Guanosine Diphosphate
• Guanosine Triphosphate
• Molecular Dynamics Simulation
• Mutation
• Protein Binding
• Protein Conformation
• rac GTP-Binding Proteins

Identifiers and source

Literature Corpus work

68d46045-0678-5659-88b6-38579d077958

DOI

10.64898/2026.04.17.719286