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Article

Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding.

Biophysical journal - 2 Mar 2021

Acuner Saliha Ece, Sumbul Fidan, Torun Hamdi, Haliloglu Turkan

Abstract excerpt

Rac1 is a small member of the Rho GTPase family. One of the most important downstream effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational activation of PAK1 by Rac1 has oncogenic signaling effects. Here, although we focus on Rac1-PAK1 interaction by atomic-force-microscopy-based single-molecule force spectroscopy experiments, we explore the effect of active mutations on the...

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Identifiers

PMID: 33515600
DOI: 10.1016/j.bpj.2021.01.016
PMCID: PMC8008323

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