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Article

Serine-71 phosphorylation of Rac1 modulates downstream signaling.

PloS one - 1 Jan 2012

Schwarz Janett, Proff Julia, Hävemeier Anika, Ladwein Markus, Rottner Klemens, Barlag Britta, Pich Andreas, Tatge Helma, Just Ingo, Gerhard Ralf

Abstract excerpt

The Rho GTPases Rac1 and Cdc42 regulate a variety of cellular functions by signaling to different signal pathways. It is believed that the presence of a specific effector at the location of GTPase activation determines the route of downstream signaling. We previously reported about EGF-induced Ser-71 phosphorylation of Rac1/Cdc42. By using the phosphomimetic S71E-mutants of Rac1 and Cdc42 we investigated the...

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Identifiers

PMID: 22970203
DOI: 10.1371/journal.pone.0044358
PMCID: PMC3438190

Genes

EGF
IQGAP1
PAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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