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Article

ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.

Neuron - 8 Dec 2011

Miśkiewicz Katarzyna, Jose Liya E, Bento-Abreu André, Fislage Marcus, Taes Ines, Kasprowicz Jarosław, Swerts Jef, Sigrist Stephan, Versées Wim, Robberecht Wim, Verstreken Patrik

Abstract excerpt

Elongator protein 3 (ELP3) acetylates histones in the nucleus but also plays a role in the cytoplasm. Here, we report that in Drosophila neurons, ELP3 is necessary and sufficient to acetylate the ELKS family member Bruchpilot, an integral component of the presynaptic density where neurotransmitters are released. We find that in elp3 mutants, presynaptic densities assemble normally, but they show morphological...

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Source

Identifiers

PMID: 22153374
DOI: 10.1016/j.neuron.2011.10.010

Genes

ELP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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