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Article

Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Oct 2005

Wu Chunlai, Wairkar Yogesh P, Collins Catherine A, DiAntonio Aaron

Abstract excerpt

Highwire is a huge, evolutionarily conserved protein that is required to restrain synaptic growth and promote synaptic transmission at the Drosophila neuromuscular junction. Current models of highwire function suggest that it may act as a ubiquitin ligase to regulate synaptic development. However, it is not known in which cells highwire functions, whether its putative ligase domain is required for function, or...

Topics

Animals
Drosophila
Drosophila Proteins
Female
Male
Mutation
Nerve Tissue Proteins
Neuromuscular Junction
Time Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16237161
DOI: 10.1523/JNEUROSCI.2532-05.2005
PMCID: PMC6725727

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