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Article

Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Oct 2005

Wu Chunlai, Wairkar Yogesh P, Collins Catherine A, DiAntonio Aaron

Abstract excerpt

Highwire is a huge, evolutionarily conserved protein that is required to restrain synaptic growth and promote synaptic transmission at the Drosophila neuromuscular junction. Current models of highwire function suggest that it may act as a ubiquitin ligase to regulate synaptic development. However, it is not known in which cells highwire functions, whether its putative ligase domain is required for function, or...

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Identifiers

PMID: 16237161
DOI: 10.1523/JNEUROSCI.2532-05.2005
PMCID: PMC6725727

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