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Article

Rapid testing of SNPs and gene-environment interactions in case-parent trio data based on exact analytic parameter estimation.

Biometrics - 1 Sept 2012

Schwender Holger, Taub Margaret A, Beaty Terri H, Marazita Mary L, Ruczinski Ingo

Abstract excerpt

Case-parent trio studies concerned with children affected by a disease and their parents aim to detect single nucleotide polymorphisms (SNPs) showing a preferential transmission of alleles from the parents to their affected offspring. A popular statistical test for detecting such SNPs associated with disease in this study design is the genotypic transmission/disequilibrium test (gTDT) based on a conditional...

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PMID: 22150644
DOI: 10.1111/j.1541-0420.2011.01713.x
PMCID: PMC3387527

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