Testing for genetic association with constrained models using triads.

Abstract excerpt

It has been shown that it is preferable to use a robust model that incorporated constraints on the genotype relative risk rather than rely on a model that assumes the disease operates in a recessive or dominant fashion. Previous methods are applicable to case-control studies, but not to family based studies of case children along with their parents (triads). We show here how to implement analogous constraints...

Topics

• Case-Control Studies
• Child
• Family
• Female
• Humans
• Ireland
• Male
• Methylenetetrahydrofolate Reductase (NADPH2)
• Models, Genetic
• Models, Statistical
• Neural Tube Defects
• Parents
• Polymorphism, Single Nucleotide