Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies.

Genetic epidemiology - 1 Jul 2022

Ray Debashree, Vergara Candelaria, Taub Margaret A, Wojcik Genevieve, Ladd-Acosta Christine, Beaty Terri H, Duggal Priya

Abstract excerpt

Genetic association studies of child health outcomes often employ family-based study designs. One of the most popular family-based designs is the case-parent trio design that considers the smallest possible nuclear family consisting of two parents and their affected child. This trio design is particularly advantageous for studying relatively rare disorders because it is less prone to type 1 error inflation due to...

Topics

Join the communities discussing this publication.

Benchmarking
Cleft Lip
Cleft Palate
Genetic Association Studies
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parent-Child Relations

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 35451532
DOI: 10.1002/gepi.22453
PMCID: PMC9356976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies.PMID 35451532Read ↗

A hybrid design: case-parent triads supplemented by control-mother dyads.Semantic proximity Read ↗

Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected.Semantic proximity Read ↗

An efficient study design to test parent-of-origin effects in family trios.Semantic proximity Read ↗

Combining case-control and case-trio data from the same population in genetic association analyses: overview of approaches and illustration with a candidate gene study.Semantic proximity Read ↗

A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.Semantic proximity Read ↗

Detecting disease variants in case-parent trio studies using the bioconductor software package trio.Semantic proximity Read ↗

Estimation of Direct and Indirect Polygenic Effects and Gene-Environment Interactions using Polygenic Scores in Case-Parent Trio StudiesSemantic proximity Read ↗

Disentangling pooled triad genotypes for association studies.Semantic proximity Read ↗

Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".Semantic proximity Read ↗

A novel test for detecting gene-gene interactions in trio studiesSemantic proximity Read ↗

Association methods in human genetics.Semantic proximity Read ↗

Efficient genome-wide association testing of gene-environment interaction in case-parent trios.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.