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Article

The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.

PLoS genetics - 1 Nov 2011

Friederichs Jennifer M, Ghosh Suman, Smoyer Christine J, McCroskey Scott, Miller Brandon D, Weaver Kyle J, Delventhal Kym M, Unruh Jay, Slaughter Brian D, Jaspersen Sue L

Abstract excerpt

The budding yeast spindle pole body (SPB) is anchored in the nuclear envelope so that it can simultaneously nucleate both nuclear and cytoplasmic microtubules. During SPB duplication, the newly formed SPB is inserted into the nuclear membrane. The mechanism of SPB insertion is poorly understood but likely involves the action of integral membrane proteins to mediate changes in the nuclear envelope itself, such as...

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Identifiers

PMID: 22125491
DOI: 10.1371/journal.pgen.1002365
PMCID: PMC3219597

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Research trail→

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The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.PMID 22125491Read ↗

Changes in the nuclear envelope environment affect spindle pole body duplication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1.Semantic proximity Read ↗

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.Semantic proximity Read ↗

Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis.Semantic proximity Read ↗

Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z.Semantic proximity Read ↗

Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.Semantic proximity Read ↗

The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion.Semantic proximity Read ↗

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.Semantic proximity Read ↗

Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes.Semantic proximity Read ↗

The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.Semantic proximity Read ↗

Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane.Semantic proximity Read ↗

The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly.Semantic proximity Read ↗

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