Article
Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1.
G3 (Bethesda, Md.) - 1 Dec 2012
Friederichs Jennifer M, Gardner Jennifer M, Smoyer Christine J, Whetstine Christine R, Gogol Madelaine, Slaughter Brian D, Jaspersen Sue L
Abstract excerpt
In virtually all eukaryotic cells, protein bridges formed by the conserved inner nuclear membrane SUN (for Sad1-UNC-84) domain-containing proteins and their outer nuclear membrane binding partners span the nuclear envelope (NE) to connect the nucleoplasm and cytoplasm. These linkages are important for chromosome movements within the nucleus during meiotic prophase and are essential for nuclear migration and...
Topics
- Alleles
- Cell Cycle Checkpoints
- Chromosomes
- Endoplasmic Reticulum
- Membrane Proteins
- Mutation
- Nuclear Envelope
- Nuclear Proteins
- Protein Binding
- Protein Structure, Tertiary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins