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Article

Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.

The Journal of cell biology - 23 Dec 2002

Jaspersen Sue L, Giddings Thomas H, Winey Mark

Abstract excerpt

Accurate duplication of the Saccharomyces cerevisiae spindle pole body (SPB) is required for formation of a bipolar mitotic spindle. We identified mutants in SPB assembly by screening a temperature-sensitive collection of yeast for defects in SPB incorporation of a fluorescently marked integral SPB component, Spc42p. One SPB assembly mutant contained a mutation in a previously uncharacterized open reading frame...

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Identifiers

PMID: 12486115
DOI: 10.1083/jcb.200208169
PMCID: PMC2173979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.PMID 12486115Read ↗

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.Semantic proximity Read ↗

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.Semantic proximity Read ↗

Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication.Semantic proximity Read ↗

The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p.Semantic proximity Read ↗

N-terminal regions of Mps1 kinase determine functional bifurcation.Semantic proximity Read ↗

The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.Semantic proximity Read ↗

Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1.Semantic proximity Read ↗

The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.Semantic proximity Read ↗

Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication.Semantic proximity Read ↗

The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion.Semantic proximity Read ↗

The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity.Semantic proximity Read ↗

Mps1p regulates meiotic spindle pole body duplication in addition to having novel roles during sporulation.Semantic proximity Read ↗

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