Article
Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes.
The Journal of cell biology - 7 Aug 2017
Rüthnick Diana, Neuner Annett, Dietrich Franziska, Kirrmaier Daniel, Engel Ulrike, Knop Michael, Schiebel Elmar
Abstract excerpt
The spindle pole body (SPB) of budding yeast duplicates once per cell cycle. In G1, the satellite, an SPB precursor, assembles next to the mother SPB (mSPB) on the cytoplasmic side of the nuclear envelope (NE). How the growing satellite subsequently inserts into the NE is an open question. To address this, we have uncoupled satellite growth from NE insertion. We show that the bridge structure that separates the...
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