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Article

Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane.

Nature communications - 2 Dec 2024

Romanauska Anete, Stankunas Edvinas, Schuldiner Maya, Köhler Alwin

Abstract excerpt

The nuclear envelope is a specialized subdomain of the endoplasmic reticulum and comprises the inner and outer nuclear membranes. Despite the crucial role of the inner nuclear membrane in genome regulation, its lipid metabolism remains poorly understood. Phosphatidic acid (PA) is essential for membrane growth as well as lipid storage. Using a genome-wide lipid biosensor screen in S. cerevisiae, we identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39622802
DOI: 10.1038/s41467-024-54811-z
PMCID: PMC11612446

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