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Article

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.

The Journal of cell biology - 1 Aug 1991

Winey M, Goetsch L, Baum P, Byers B

Abstract excerpt

It is crucial to the eucaryotic cell cycle that the centrosome undergo precise duplication to generate the two poles of the mitotic spindle. In the budding yeast Saccharomyces cerevisiae, centrosomal functions are provided by the spindle pole body (SPB), which is duplicated at the time of bud emergence in G1 of the cell cycle. Genetic control of this process has previously been revealed by the characterization of...

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Identifiers

PMID: 1869587
DOI: 10.1083/jcb.114.4.745
PMCID: PMC2289888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.PMID 1869587Read ↗

Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.Semantic proximity Read ↗

N-terminal regions of Mps1 kinase determine functional bifurcation.Semantic proximity Read ↗

Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1.Semantic proximity Read ↗

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.Semantic proximity Read ↗

The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.Semantic proximity Read ↗

The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p.Semantic proximity Read ↗

Mps1p regulates meiotic spindle pole body duplication in addition to having novel roles during sporulation.Semantic proximity Read ↗

Spindle regulation: Mps1 flies into new areas.Semantic proximity Read ↗

Genetic determinants of spindle pole body duplication in budding yeast.Semantic proximity Read ↗

Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication.Semantic proximity Read ↗

Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.Semantic proximity Read ↗

The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1.Semantic proximity Read ↗

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