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Article

Changes in the nuclear envelope environment affect spindle pole body duplication in Saccharomyces cerevisiae.

Genetics - 1 Nov 2010

Witkin Keren L, Friederichs Jennifer M, Cohen-Fix Orna, Jaspersen Sue L

Abstract excerpt

The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body. To study how properties of the nuclear membrane affect nuclear envelope processes, we altered the nuclear membrane by deleting the SPO7 gene. We found that spo7Δ...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20713690
DOI: 10.1534/genetics.110.119149
PMCID: PMC2975299

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Changes in the nuclear envelope environment affect spindle pole body duplication in Saccharomyces cerevisiae.PMID 20713690Read ↗

The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.Semantic proximity Read ↗

Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1.Semantic proximity Read ↗

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.Semantic proximity Read ↗

The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion.Semantic proximity Read ↗

Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes.Semantic proximity Read ↗

The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.Semantic proximity Read ↗

Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p.Semantic proximity Read ↗

Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion.Semantic proximity Read ↗

The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis.Semantic proximity Read ↗

Genetic determinants of spindle pole body duplication in budding yeast.Semantic proximity Read ↗

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