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Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

28 Nov 2011

Abstract excerpt

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1-DNA cleavage complexes (Top1cc's) and inducing replication-associated DNA double-strand breaks (DSBs). In this paper, we propose a new mechanism by which cells...

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PMID: 22123861
DOI: 10.1083/jcb.201104003

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