Article

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

2021-10-12

Abstract excerpt

Topoisomerase II (Top2) unlinks chromosomes during vertebrate DNA replication. Top2 ‘poisons’ are widely-used chemotherapeutics that stabilize Top2 complexes on DNA, leading to cytotoxic DNA breaks. However, it is unclear how these drugs affect DNA replication, which is a major target of Top2 poisons. Using Xenopus egg extracts, we show that the Top2 poisons etoposide and doxorubicin both inhibit DNA replication...

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Literature Corpus work: 5811d7ad-8449-593b-982d-2d3ff3ac1383
DOI: 10.1101/2021.10.12.464107

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