Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription

1 Jan 2015

Abstract excerpt

Camptothecin (CPT) inhibits DNA topoisomerase I (Top1) through a non-catalytic mechanism that stabilizes the Top1-DNA cleavage complex (Top1cc) and blocks the DNA re-ligation step, resulting in the accumulation in the genome of DNA single-strand breaks (SSBs), which are converted to secondary strand breaks when they collide with the DNA replication and RNA transcription machinery. DNA strand breaks mediated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26616758
DOI: 10.1266/ggs.15-00023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcriptionPMID 26616758Read ↗

The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damageSemantic proximity Read ↗

Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposideSemantic proximity Read ↗

Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapySemantic proximity Read ↗

Repair of DNA Breaks by Break-Induced Replication.Semantic proximity Read ↗

Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage responseSemantic proximity Read ↗

DNA repair pathways and cisplatin resistance: an intimate relationshipSemantic proximity Read ↗

Minimal Resection Takes Place during Break-Induced Replication Repair of Collapsed Replication Forks and Is Controlled by Strand InvasionSemantic proximity Read ↗

DNA double-strand break repair in a cellular context.Semantic proximity Read ↗

Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy.Semantic proximity Read ↗

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.Semantic proximity Read ↗

DNA replication stress and cancer chemotherapySemantic proximity Read ↗

Topoisomerase-Mediated DNA Damage in Neurological DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.