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Article

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.

Nucleic acids research - 16 Nov 2015

Iannascoli Chiara, Palermo Valentina, Murfuni Ivana, Franchitto Annapaola, Pichierri Pietro

Abstract excerpt

The WRN helicase/exonuclease protein is required for proper replication fork recovery and maintenance of genome stability. However, whether the different catalytic activities of WRN cooperate to recover replication forks in vivo is unknown. Here, we show that, in response to replication perturbation induced by low doses of the TOP1 inhibitor camptothecin, loss of the WRN exonuclease resulted in enhanced...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26275776
DOI: 10.1093/nar/gkv836
PMCID: PMC4787784

Genes

WRN
EXO1
MRE11
DNA2
RAD51
TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.PMID 26275776Read ↗

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