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Topoisomerases and cancer chemotherapy: recent advances and unanswered questions

30 Sept 2019

Abstract excerpt

DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both prokaryotes and eukaryotes, including DNA replication, transcription, recombination, and chromosome segregation. Studies performed over the past 3 years have provided new insight into the roles of various topoisomerases in...

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PMID: 31602296
DOI: 10.12688/f1000research.20201.1

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