Article
Identification of an mtDNA mutation hot spot in UV-induced mouse skin tumors producing altered cellular biochemistry.
The Journal of investigative dermatology - 1 Feb 2012
Jandova Jana, Eshaghian Alex, Shi Mingjian, Li Meiling, King Lloyd E, Janda Jaroslav, Sligh James E
Abstract excerpt
There is increasing awareness of the role of mtDNA alterations in the development of cancer, as mtDNA point mutations are found at high frequency in a variety of human tumors. To determine the biological effects of mtDNA mutations in UV-induced skin tumors, hairless mice were irradiated to produce tumors, and the tumor mtDNAs were screened for single-nucleotide changes using temperature gradient capillary...
Topics
- Adenosine Triphosphate
- Animals
- DNA, Mitochondrial
- Female
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Neoplasms, Radiation-Induced
- Oxygen Consumption
- RNA, Transfer, Arg
- Skin Neoplasms