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Article

Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects.

Biochemical and biophysical research communications - 27 Nov 2015

Shimizu Akinori, Enoki Shunkei, Ishikawa Kaori, Mito Takayuki, Obata Kanae, Nagashima Ruriko, Yonekawa Hiromichi, Nakada Kazuto, Hayashi Jun-Ichi

Abstract excerpt

We searched for mtDNA harboring somatic mutations in mouse B82 cells, and found an A2748G mutation orthologous to the A3302G mutation in tRNA(Leu(UUR)) gene reported in a patient with MELAS, the most prevalent mitochondrial disease. We isolated subclones of B82 cells until we obtained one subclone harboring >95% A2748G mtDNA. Cytoplasmic transfer of A2748G mtDNA resulted in cotransfer of A2748G mtDNA and...

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PMID: 26381171
DOI: 10.1016/j.bbrc.2015.09.072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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