Mitochondrial tRNA-Derived Fragments as Candidate Metastasis-Modifying RNA.

doi:10.1158/2767-9764.CRC-26-0360

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Mitochondrial tRNA-Derived Fragments as Candidate Metastasis-Modifying RNA.

Cancer research communications - 1 Aug 2026

Swancutt Katy L, Walsh R McKinnon, Quijano Sydney, Schueddig Emily, Koestler Devin C, Scheid Adam D, Bush Tony Vanden, Jing Yi, Rigoutsos Isidore, Welch Danny R

Abstract excerpt

How mitochondrial DNA (mtDNA) polymorphisms influence complex phenotypes remains poorly understood. Using mitochondrial-nuclear exchange mice, we previously showed that mtDNA single-nucleotide polymorphisms (SNP) modify metastasis, cardiovascular disease, and epigenetic marks independently of metabolic differences. The only mtDNA SNP correlating with these phenotypes resides in the gene encoding mitochondrial...

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DNA, Mitochondrial
Mice
Mitochondria
Neoplasm Metastasis
Polymorphism, Single Nucleotide
RNA, Mitochondrial

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PMID: 42579886
DOI: 10.1158/2767-9764.CRC-26-0360
PMCID: PMC13522972

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