Article
Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response.
PloS one - 1 Jan 2020
Lopez Sanchez M Isabel G, Ziemann Mark, Bachem Annabell, Makam Rahul, Crowston Jonathan G, Pinkert Carl A, McKenzie Matthew, Bedoui Sammy, Trounce Ian A
Abstract excerpt
Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expression of the nuclear and mitochondrial genomes. This represents a unique challenge that highlights the importance of nuclear-mitochondrial genetic communication to cellular function. Here we investigated the transcriptomic and functional consequences of nuclear-mitochondrial genetic...
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