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Article

Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway.

Enzyme and microbial technology - 10 Jun 2011

Tang Zhenyu, Xiao Ciying, Zhuang Yingping, Chu Ju, Zhang Siliang, Herron Paul R, Hunter Iain S, Guo Meijin

Abstract excerpt

The aromatic polyketide antibiotic, oxytetracycline (OTC), is produced by Streptomyces rimosus as an important secondary metabolite. High level production of antibiotics in Streptomycetes requires precursors and cofactors which are derived from primary metabolism; therefore it is exigent to engineer the primary metabolism. This has been demonstrated by targeting a key enzyme in the oxidative pentose phosphate...

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PMID: 22112266
DOI: 10.1016/j.enzmictec.2011.04.002

Genes

OTC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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