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Development of a CRISPR/Cas9-mediated gene-editing tool in Streptomyces rimosus.

Microbiology (Reading, England) - 1 Aug 2017

Jia Haiyan, Zhang Longmei, Wang Tongtong, Han Jin, Tang Hui, Zhang Liping

Abstract excerpt

Clustered regularly interspaced short palindromic repeats, associated proteins (CRISPR/Cas), has been developed into a powerful, targeted genome-editing tool in a wide variety of species. Here, we report an extensive investigation of the type II CRISPR/Cas9 system for targeted gene editing in Streptomyces rimosus. S. rimosus is used in the production of the antibiotic oxytetracycline, and its genome differs...

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PMID: 28742008
DOI: 10.1099/mic.0.000501

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PAM

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