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Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer.

Microbial cell factories - 28 Oct 2023

Beganovic Selma, Rückert-Reed Christian, Sucipto Hilda, Shu Wei, Gläser Lars, Patschkowski Thomas, Struck Ben, Kalinowski Jörn, Luzhetskyy Andriy, Wittmann Christoph

Abstract excerpt

BACKGROUND: Oxytetracycline which is derived from Streptomyces rimosus, inhibits a wide range of bacteria and is industrially important. The underlying biosynthetic processes are complex and hinder rational engineering, so industrial manufacturing currently relies on classical mutants for production. While the biochemistry underlying oxytetracycline synthesis is known to involve polyketide synthase,...

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PMID: 37898787
DOI: 10.1186/s12934-023-02215-x
PMCID: PMC10612213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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