Article

Combined use of design of experiments and metabolic engineering for optimization of nogalamycin production

2019-10-13

Abstract excerpt

<h4>ABSTRACT</h4> Nogalamycin is an anthracycline antibiotic produced from Streptomyces nogalater that exerts its mechanism of action via inhibition of topoisomerase I. Nogalamycin has a unique tetracyclic structure composed of a 7- O -glycosidically linked L-nogalose sugar and a C2-C5”-linked L-nogalamine residue that forms an epoxyoxacin ring. Nogalamycin was originally developed as an anticancer agent in the...

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Literature Corpus work: e45b0bc5-77e2-5fd6-978a-c90ebb23ade4
DOI: 10.1101/804179

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