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Article

ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradation.

PloS one - 1 Jan 2024

Zhu Xuechen, Wang Rongbin, Siitonen Vilja, Vuksanovic Nemanja, Silvaggi Nicholas R, Melançon Iii Charles E, Metsä-Ketelä Mikko

Abstract excerpt

The biosynthetic pathway of actinorhodin in Streptomyces coelicolor A3(2) has been studied for decades as a model system of type II polyketide biosynthesis. The actinorhodin biosynthetic gene cluster includes a gene, actVI-orfA, that encodes a protein that belongs to the nuclear transport factor-2-like (NTF-2-like) superfamily. The function of this ActVI-ORFA protein has been a long-standing question in this...

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PMID: 39121077
DOI: 10.1371/journal.pone.0308684
PMCID: PMC11315284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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