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Article

Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function.

Nucleic acids research - 1 Mar 2012

Martínez Allyson K, Shirole Nitin H, Murakami Shino, Benedik Michael J, Sachs Matthew S, Cruz-Vera Luis R

Abstract excerpt

Translation of the TnaC nascent peptide inhibits ribosomal activity in the presence of l-tryptophan, inducing expression of the tnaCAB operon in Escherichia coli. Using chemical methylation, this work reveals how interactions between TnaC and the ribosome are affected by mutations in both molecules. The presence of the TnaC-tRNA(Pro) peptidyl-tRNA within the ribosome protects the 23S rRNA nucleotide U2609 against...

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Identifiers

PMID: 22110039
DOI: 10.1093/nar/gkr1052
PMCID: PMC3299997

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Source receipt: pubmed, retrieved 7 Sept 2026.

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