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Article

Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications.

Journal of bacteriology - 1 Dec 2008

Monshupanee Tanakarn, Gregory Steven T, Douthwaite Stephen, Chungjatupornchai Wipa, Dahlberg Albert E

Abstract excerpt

Translocation during the elongation phase of protein synthesis involves the relative movement of the 30S and 50S ribosomal subunits. This movement is the target of tuberactinomycin antibiotics. Here, we describe the isolation and characterization of mutants of Thermus thermophilus selected for resistance to the tuberactinomycin antibiotic capreomycin. Two base substitutions, A1913U and mU1915G, and a single base...

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Identifiers

PMID: 18805973
DOI: 10.1128/JB.00984-08
PMCID: PMC2583624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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