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Article

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.

Molecular cell - 1 Jan 2003

Polacek Norbert, Gomez Maria J, Ito Koichi, Xiong Liqun, Nakamura Yoshikazu, Mankin Alexander

Abstract excerpt

The ribosomal peptidyl transferase center is responsible for two fundamental reactions, peptide bond formation and nascent peptide release, during the elongation and termination phases of protein synthesis, respectively. We used in vitro genetics to investigate the functional importance of conserved 23S rRNA nucleotides located in the peptidyl transferase active site for transpeptidation and peptidyl-tRNA...

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Identifiers

PMID: 12535525
DOI: 10.1016/s1097-2765(02)00825-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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