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Article

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs.

Molecular cell - 21 Jul 2006

Johansen Shanna K, Maus Courtney E, Plikaytis Bonnie B, Douthwaite Stephen

Abstract excerpt

The cyclic peptide antibiotics capreomycin and viomycin are generally effective against the bacterial pathogen Mycobacterium tuberculosis. However, recent virulent isolates have become resistant by inactivation of their tlyA gene. We show here that tlyA encodes a 2'-O-methyltransferase that modifies nucleotide C1409 in helix 44 of 16S rRNA and nucleotide C1920 in helix 69 of 23S rRNA. Loss of these previously...

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Share to RNA, Ribosomal, 16S
Share to Antibiotics, Antitubercular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Methylation

Share to Nucleic Acid Conformation

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Share to RNA, Bacterial

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Source

Identifiers

PMID: 16857584
DOI: 10.1016/j.molcel.2006.05.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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