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Article

Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.

Nucleic acids research - 1 Jan 2014

Martínez Allyson K, Gordon Emily, Sengupta Arnab, Shirole Nitin, Klepacki Dorota, Martinez-Garriga Blanca, Brown Lewis M, Benedik Michael J, Yanofsky Charles, Mankin Alexander S, Vazquez-Laslop Nora, Sachs Matthew S, Cruz-Vera Luis R

Abstract excerpt

A transcriptional attenuation mechanism regulates expression of the bacterial tnaCAB operon. This mechanism requires ribosomal arrest induced by the regulatory nascent TnaC peptide in response to free L-tryptophan (L-Trp). In this study we demonstrate, using genetic and biochemical analyses, that in Escherichia coli, TnaC residue I19 and 23S rRNA nucleotide A2058 are essential for the ribosome's ability to sense...

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PMID: 24137004
DOI: 10.1093/nar/gkt923
PMCID: PMC3902921

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.PMID 24137004Read ↗

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