Article
Post-transfer editing in vitro and in vivo by the beta subunit of phenylalanyl-tRNA synthetase.
The EMBO journal - 24 Nov 2004
Roy Hervé, Ling Jiqiang, Irnov Michael, Ibba Michael
Abstract excerpt
Translation of the genetic code requires attachment of tRNAs to their cognate amino acids. Errors during amino-acid activation and tRNA esterification are corrected by aminoacyl-tRNA synthetase-catalyzed editing reactions, as extensively described for aliphatic amino acids. The contribution of editing to aromatic amino-acid discrimination is less well understood. We show that phenylalanyl-tRNA synthetase...
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