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Article

Substrate tRNA recognition mechanism of eubacterial tRNA (m1A58) methyltransferase (TrmI).

The Journal of biological chemistry - 27 Feb 2015

Takuma Hiroyuki, Ushio Natsumi, Minoji Masayuki, Kazayama Ai, Shigi Naoki, Hirata Akira, Tomikawa Chie, Ochi Anna, Hori Hiroyuki

Abstract excerpt

TrmI generates N(1)-methyladenosine at position 58 (m(1)A58) in tRNA. The Thermus thermophilus tRNA(Phe) transcript was methylated efficiently by T. thermophilus TrmI, whereas the yeast tRNA(Phe) transcript was poorly methylated. Fourteen chimeric tRNA transcripts derived from these two tRNAs revealed that TrmI recognized the combination of aminoacyl stem, variable region, and T-loop. This was confirmed by 10...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25593312
DOI: 10.1074/jbc.M114.606038
PMCID: PMC4342497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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