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Article

Features of ribosome-peptidyl-tRNA interactions essential for tryptophan induction of tna operon expression.

Molecular cell - 5 Aug 2005

Cruz-Vera Luis Rogelio, Rajagopal Soumitra, Squires Catherine, Yanofsky Charles

Abstract excerpt

Certain nascent peptide sequences, when within the ribosomal exit tunnel, can inhibit translation termination and/or peptide elongation. The 24 residue leader peptidyl-tRNA of the tna operon of E. coli, TnaC-tRNA(Pro), in the presence of excess tryptophan, resists cleavage at the tnaC stop codon. TnaC residue Trp12 is crucial for this inhibition. The approximate location of Trp12 in the exit tunnel was determined...

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PMID: 16061180
DOI: 10.1016/j.molcel.2005.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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