Article
Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2012
Naicker Dshanta D, Wang Bingxia, Losina Elena, Zupkosky Jennifer, Bryan Susan, Reddy Shabashini, Jaggernath Manjeetha, Mokgoro Mammekwa, Goulder Philip J R, Kaufmann Daniel E, Ndung'u Thumbi
Abstract excerpt
BACKGROUND: Interleukin-10 (IL-10) is a potent immunoregulatory cytokine. IL-10-promoter polymorphisms have been shown to affect human immunodeficiency virus type 1 (HIV-1) clinical outcomes but the underlying mechanisms are poorly understood. METHODS: We investigated the relationship between IL-10-promoter variants, plasma cytokine levels, immune responses and markers of disease outcome in antiretroviral-naïve...
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