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Article

Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis.

The Journal of infectious diseases - 1 Aug 2009

Naicker Dshanta D, Werner Lise, Kormuth Emil, Passmore Jo-Ann, Mlisana Koleka, Karim Salim Abdool, Ndung'u Thumbi

Abstract excerpt

Interleukin (IL)-10 directly inhibits human immunodeficiency virus type 1 (HIV-1) replication, but it may also promote viral persistence by inactivation of effector immune mechanisms. Here, we show in an African cohort that individuals with genotypes associated with high IL-10 production at 2 promoter single-nucleotide polymorphisms (-1082 and -592) were less likely to become HIV-1 infected but had significantly...

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Source

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Identifiers

PMID: 19534595
DOI: 10.1086/600072
PMCID: PMC3137931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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