Article
Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy.
Human immunology - 1 Apr 2017
Dmello Deane Maria, Ariyanto Ibnu, Estiasari Riwanti, Halstrom Samuel, Gaff Jessica, Lee Silvia, Price Patricia
Abstract excerpt
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12months on treatment. Heterozygosity at or associated with low...