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Article

Extended IL10 haplotypes and their association with HIV progression to AIDS.

Genes and immunity - 1 Jun 2009

Oleksyk T K, Shrestha S, Truelove A L, Goedert J J, Donfield S M, Phair J, Mehta S, O'Brien S J, Smith M W

Abstract excerpt

Interleukin-10 (IL-10) is a pleiotropic cytokine with both immunosuppressive and immunostimulatory functions. Its roles in infections and autoimmunity may have resulted in selective pressures on polymorphisms within the gene, leading to genomic coexistence of several semi-conserved haplotypes involved with diverse pathogen interactions during genomic evolution. Previous studies focused either exclusively on...

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Identifiers

PMID: 19295541
DOI: 10.1038/gene.2009.9
PMCID: PMC3664918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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