Article
Frequencies of IL10 SNP genotypes by multiplex PCR-SSP and their association with viral load and CD4 counts in HIV-1-infected Thais.
Asian Pacific journal of allergy and immunology - 1 Mar 2011
Kingkeow Doungnapa, McNicholl Janet M, Maneekarn Niwat, Wongtrakul Jeerang, Taechareonkul Sineenart, Suriyanon Vinai, Nelson Kenrad E, Duerr Ann, Makonkawkeyoon Sanit
Abstract excerpt
BACKGROUND: Interleukin (IL)-10 is an immunoregulatory cytokine, levels of which can be influenced by single nucleotide polymorphisms (SNPs) in the promoter. Some, but not all previous studies have shown associations of IL10 SNPs with HIV-1 disease progression, using markers such as viral load or CD4 count. There are few data on IL10 SNP frequencies and HIV-1 disease in regions where non-B HIV-1 subtypes...
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