Article
Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2022
Koning Dan, Quakkelaar Esther D, Schellens Ingrid M M, Spierings Eric, van Baarle Debbie
Abstract excerpt
CD8+ T cells play an important role in the control of untreated HIV infection. Several studies have suggested a decisive role of TCRs involved in anti-HIV immunity. HLA-B*27 and B*57 are often associated with a delayed HIV disease progression, but the exact correlates that provide superior immunity against HIV are not known. To investigate if the T cell repertoire underlies the protective effect in disease...
Topics
- Alleles
- Antigen Presentation
- Antigens, Viral
- Cells, Cultured
- Complementarity Determining Regions
- Cross Reactions
- Disease Progression
- Enzyme-Linked Immunospot Assay
- Epitopes, T-Lymphocyte
- Genetic Variation
- HIV Infections
- HIV-1
- HLA-B Antigens