Article
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2011
Zhang Hao, Cordoba Shaun-Paul, Dushek Omer, van der Merwe P Anton
Abstract excerpt
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation...
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