Article
TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.
Science signaling - 23 Mar 2021
Connolly Audrey, Panes Rébecca, Tual Margaux, Lafortune Raphaël, Bellemare-Pelletier Angélique, Gagnon Etienne
Abstract excerpt
Electrostatic interactions regulate many aspects of T cell receptor (TCR) activity, including enabling the dynamic binding of the TCR-associated CD3ε and CD3ζ chains to anionic lipids in the plasma membrane to prevent spontaneous phosphorylation. Substantial changes in the electrostatic potential of the plasma membrane occur at the immunological synapse, the interface between a T cell and an antigen-presenting...
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