Article
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
Science (New York, N.Y.) - 25 Feb 1994
Iwashima M, Irving B A, van Oers N S, Chan A C, Weiss A
Abstract excerpt
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCR zeta and CD3 chains. TCR stimulation induces the tyrosine p...
Topics
- Amino Acid Sequence
- Animals
- CD8 Antigens
- Cell Line
- Cytoplasm
- Haplorhini
- Humans
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell
- Signal Transduction
- Tumor Cells, Cultured
- Tyrosine