Article
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
Science (New York, N.Y.) - 25 Feb 1994
Iwashima M, Irving B A, van Oers N S, Chan A C, Weiss A
Abstract excerpt
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCR zeta and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation...
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