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Article

Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.

Immunity - 1 Mar 2007

Kuhns Michael S, Davis Mark M

Abstract excerpt

The alphabeta T cell antigen receptor (TCR), in complex with the CD3deltavarepsilon, gammavarepsilon, and zetazeta signaling subunits, is the chief determinant for specific CD4(+) and CD8(+) T cell responses to self and foreign antigens. Although transmembrane domain charge interactions are critical for the assembly of the complex, the location of extracellular contacts between the TCR and CD3 subunits and their...

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Source

Identifiers

PMID: 17368054
DOI: 10.1016/j.immuni.2007.01.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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