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Article

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.

The EMBO journal - 15 Oct 2001

Kang S W, Wahl M I, Chu J, Kitaura J, Kawakami Y, Kato R M, Tabuchi R, Tarakhovsky A, Kawakami T, Turck C W, Witte O N, Rawlings D J

Abstract excerpt

Mutations in Bruton's tyrosine kinase (Btk) result in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. While targeted disruption of the protein kinase C-beta (PKCbeta) gene in mice results in an immunodeficiency similar to xid, the overall tyrosine phosphorylation of Btk is significantly enhanced in PKCbeta-deficient B cells. We provide direct evidence that PKCbeta acts as...

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Identifiers

PMID: 11598012
DOI: 10.1093/emboj/20.20.5692
PMCID: PMC125669

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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